Events from the year 1621 in Denmark.
Incumbents
- Monarch – Christian IV
Events
- Maribo Abbey closes, and its lands eventually become part of Sorø Academy
Births
- 8 July – Leonora Christina Ulfeldt, daughter of Christian IV and Countess of Schleswig-Holstein (died 1698)
Deaths
- 8 March – Enevold Kruse, nobleman who served as Governor-general of Norway (born 1554)
- 26 June – Christence Kruckow, noblewoman and accused witch (born c. 1558)
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