Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer. Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).

Early trials with yttrium (90Y) capromab pendetide were also conducted.

References



Diagnostic Performance of In111 Capromab Pendetide SPECT/CT

Indium In 111 Package Insert

Indium (111In) Capromab Pendetide, 9786200229915, 6200229910

Table 1 from Clinical evaluation of indium111labeled chimeric anti

SPECT/CT images from clinical 111 Incapromab pendetide study including